Stumbling around uncharted regulatory structures: NAcrins, or the perspective of specialized sources of modulatory non-coding RNAs
Abstract
The revelation of the supreme authority of nucleic acids in the cellular landscape has precipitated the recognition of the versatility of RNAs in cells. The subsequent discovery of non-coding RNAs was a major breakthrough that revealed their extensive involvement in virtually all physiological processes within the cell. Beyond the barriers of the cell, the current perception seems to support the idea of their participation in intercellular regulation and cross-kingdom communication. However, the presence of non-coding RNAs in the extracellular environment remains essentially a mystery, and the understanding of the significance and the processes governing this presence faces several constraints. This has led us to forge an original and predictive idea that seems to allow an emancipation from the various constraints posed in the current perception of the cited phenomena. In this paper, we will attempt to explore the extent of the probable existence of cellular organizations specializing in the production and management of non-coding RNAs. We will try, through the development of this hypothesis, to draw a picture explaining the significance and logistics of extracellular non-coding RNAs, with an emphasis on microRNAs. This exercise will be realized while relying on and confronting purely theoretical points of view, as well as relevant experimental results. In this manuscript, we will address the presumed morphology, intracellular organization, selective export, transport, transfer, distribution, reception and intracellular function of non-coding RNAs, in the perspective of a regulation cycle orchestrated by NAcrins under normal or disturbed physiological contexts.